'Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours: a phase 1 trial'
Spicer J, Basu B, Montes M, Banerji U, Kristeleit R, Veal G, Corrigan C, Till S, Figini M, Canevari S, Bartn C, Jones P, Mellor S, Carroll S, Selkirk C, Nintos G, Kwatra V, Funingana I, Doherty G, Gould H, Pellizzari G, Nakamura M, Ilieva K, Khiabany A, Stavraka C, Chauhan J, Gillett C, Pinder P, Bax H, Josephs D & Karagiannis S
Nature Communications (2023) doi 10.1038/s41467-023-39679-9
‘Intra-tumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study’
Papa S, Adami A, Metoudi M, Beatson R, George M, Achkova D, Williams E, Arif S, Reid F, Elstad M, Beckley-Hoelscher N, Douri A, Delord M, Lyne M, Shivapatham D, Fisher C, Hope A, Gooljar S, Mitra A, Gomm L, Morton C, Henley-Smith R, Thavaraj S, Santambrogio A, Andoniadou C, Allen S, Gibson V, Cook G, Parente-Pereira A, Davies D, Farzaneh F, Schurich A, Guerrero-Urbano T, Jeannon J, Spicer J & Maher J.
Journal for ImmunoTherapy of Cancer (2023) doi: 10.1136/jitc-2023-007162
‘Safety, anti-tumor activity and T-cell responses in a dose-ranging phase 1 study of the oncolytic peptide LTX-315 in patients with solid tumors’
Spicer J, Marabelle A, Baurain J, Jebsen N, Jøssang D, Awada A, Kristeleit R, Loirat D, Lazaridis G, Jungels C, Brunsvig P, Nicholaisen B, Saunders A, Patel H, Galon J, Hermitte F, Camilio K, Mauseth B, Sundvold V, Sveinbjørnsson B & Reckdal Ø.
Clinical Cancer Research (2021) doi: 10.1158/1078-0432.CCR-20-3435
AACR Annual Meeting, San Diego (Virtual), April
‘Phase 1 trial of MOv18, a first-in-class IgE antibody therapy for cancer’
Spicer J, Basu B, Montes M, Banerji U, Kristeleit R, Veal G, Corrigan C, Till S, Nintos G, Brier T, Funingana I, Ang J, ZakiK, Griffin A, Barton C, Jones P, Mellor S, Brook S, Stoddart K, Selkirk C, Carroll S, Lentfer H, Woodman N, Pope A, Pellizzari G, Nakamura M, Ilieva K, Khiabany A, Stavraka C, Gould H, Chauhan J, Bax H, Pinder P, Josephs D & Karagiannis S
‘MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, Phase I trial’
Sarker D, Plummer R, Meyer T, Sodergren M, Basu B, Chee CE, Huang K, Palmer D, Ma Y, Evans T, Spalding R, Pai M, Sharma R, Pinato D, Spicer J, Hunter S, Kwatra V, Nicholls J, Collin D, Nutbrown R, Glenny H, Fairbairn S, Reebye V, Voutila J, Dorman S, Andrikakou P, Lloyd P, Felstead S, Vasara J, Habib R, Wood C, Sætrom P, Huber H, Blakey D, Rossi J & Habib N
Clinical Cancer Research (2020) doi: 10.1158/1078-0432.CCR-20-0414
ESMO Annual Meeting, Barcelona, September 2019:
‘An open-label, randomized, phase I/II trial of IO102 and pembrolizumab, or IO102, pembrolizumab and chemotherapy, as first-line treatment for patients with metastatic non-small cell lung cancer’
Spicer J, Provencio M, Garrido Lopez P, Bosch-Barrera J, de Castro Carpeño F, Felip E, Trigo J, Viteri S, Coart E, Schmidt E, Christiansen A, Zocca M, Andersen M, Ehrnrooth E & Paz-Ares L
‘A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer’
Macpherson IR, Spiliopoulou P, Rafii S, Saggese M, Baird RD, Garcia-Corbacho J, Italiano A, Bonneterre J, Campone M, Cresti N, Posner J, Takeda Y, Arimura A & Spicer J
Breast Cancer Research (2019) 22:1
‘A phase I study to assess afatinib in combination with carboplatin or with carboplatin plus paclitaxel in patients with advanced solid tumors’
O’Brien M, Sarker D, Bhosle J, Thillai K, Yap T, Uttenreuther-Fischer M, Pemberton K, Jin X, Wiebe S, de Bono J & Spicer J
Cancer Chemotherapy and Pharmacology (2018) 82:757-66
‘Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNF-α/MCP-1 signaling’
Josephs D, Bax H, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P, Cheung A, Herraiz C, Ilieva K, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S, Chiaruttini G, Gilbert AE, Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan C, Beavil AJ, Nestle F, Jones P, Gould H, Sanz-Moreno V, Blower P, Spicer J & Karagiannis S
Cancer Research (2017) 77:1127-1141
